一、个人简介
郭占勇，男，博士，研究员，博士生导师。2007年毕业于中国科学院海洋研究所，获理学博士学位，2015.9-2016.8加拿大国家研究院阿曼德-弗雷皮尔研究所访问学者。研究领域为海洋生物资源化学与生物制品，致力于糖类生物活性的构效关系研究及机理发现，并进行生物制品开发。近年来主持国家重点研发计划课题、国家自然科学基金、山东省重点研发计划课题、国家海洋局公益项目课题、中国科学院知识创新工程重要方向性项目、科技支撑计划课题、中国科学院STS计划课题、中国科学院人才项目、中国科学院院地合作项目、专利技术成果转化等课题。第一或通讯作者在Carbohydrate Polymers、Food Hydrocolloids、 Food Chemistry、International Journal of Biological Macromolecules、Journal of agricultural and food chemistry、Bioorganic Chemistry等期刊发表SCI论文130多篇，授权国家发明专利60多项，多项技术实现产业化。2024年10月任新葡的京集团3512vip研究员。
二、教学情况
指导硕士、博士研究生20多名，获得中国科学院经理特别奖3人、中国科学院优秀博士学位论文2人、朱李月华优秀博士奖2人、国家奖学金5人；《生物有机化学》获中国科学院大学2022年学院级“研究生优秀课程”。
三、主要研究项目
1、功能阴离子化壳寡糖盐的制备技术及产品开发，山东省重点研发计划 (重大科技创新工程)课题，2023.01-2025.12，409万元。
2、滩涂生物资源循环利用技术与空间功能优化策略，国家重点研发计划项目课题，2019.11-2022.12，452万元。
3、3,6-二氨基甲壳素/壳聚糖的设计、合成及抑真菌活性研究，国家自然科学基金，2016.01-2019.12，80.4万元。
4、壳寡糖衍生复合物降血糖产品开发，企业委托开发，2022.12-2024.11，80万元。
四、研究方向
海洋生物资源化学；生物制品
五、代表性论文
1. Yuting Yuan, Qiuhong Chen, Zhenhua Wang, Yingqi Mi, Fang Dong, Wenqiang Tan*, Zhanyong Guo*. Low molecular weight chitosan based GSH-responsive self-assembled cationic micelle with enhanced anti-tumor effect by combining oxidative damage and chemotherapy. International Journal of Biological Macromolecules. 2024, 268, 131736.
2. Jingmin Cui, Yanqing Wang, Xiaorui Liang, Jinyu Zhao, Yuting Ji, Wenqiang Tan, Fang Dong*, Zhanyong Guo*. Synthesis, antimicrobial activity, antioxidant activity and molecular docking of novel chitosan derivatives containing glycine Schiff bases as potential succinate dehydrogenase inhibitors. International Journal of Biological Macromolecules. 2024, 267, 131407.
3. Xiangru Han, Yingqi Mi, Yuting Ji, Mingzhi Sun, Hongxia Tang, Fang Dong, Zhanyong Guo*. A novel chitosan antioxidant bearing sulfhydryl group: Synthesis, characterization and activity assessment. International Journal of Biological Macromolecules. 2024, 261 (1), 129816.
4. Bing Ma, Qing Li, Yingqi Mi, Jingjing Zhang, Wenqiang Tan, Zhanyong Guo*. pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release. International Journal of Biological Macromolecules. 2024, 257 (1), 128590.
5. Conghao Lin, Fang Luan, Shengjia Su, Aili Jiang, Wenqiang Tan*, Zhanyong Guo*. Water-soluble fluorine-functionalized chitooligosaccharide derivatives: Synthesis, characterization and antimicrobial activity. Carbohydrate Research, 2023, 533, 108935.
6. Qing Li, Yunhui Yang, Yijian Li, Yingqi Mi, Xuanxuan Ma, Aili Jiang, Zhanyong Guo*. Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment. International Journal of Biological Macromolecules, 2023, 253, 126691.
7. Yuting Yuan, Zhenhua Wang, Shengjia Su, Yingqi Mi, Qing Li, Fang Dong, Wenqiang Tan*, Zhanyong Guo*. Redox-sensitive self-assembled micelles based on low molecular weight chitosan-lipoic acid conjugates for the delivery of doxorubicin: Effect of substitution degree of lipoic acid. International Journal of Biological Macromolecules, 2023, 247, 125849.
8. Jingmin Cui, Yan Sun, Linqing Wang, Wenqiang Tan, Zhanyong Guo*. Preparation of chitosan derivatives containing aromatic five-membered heterocycles for efficient antimicrobial and antioxidant activities. International Journal of Biological Macromolecules, 2023, 247, 125850.
9. Yuting Yuan, Zhenhua Wang, Shengjia Su, Conghao Lin, Yingqi Mi, Wenqiang Tan*, Zhanyong Guo*. Self-assembled low molecular weight chitosan-based cationic micelle for improved water solubility, stability and sustained release of α-tocopherol. Food Chemistry. 2023, 429, 136886.
10. Bing Ma, Jingjing Zhang, Yingqi Mi, Qin Miao, Wenqiang Tan, Zhanyong Guo*. Preparation of imidazole acids grafted chitosan with enhanced antioxidant, antibacterial and antitumor activities. Carbohydrate Polymers, 2023, 315, 120978.
11. Yuting Yuan, Wenqiang Tan*, Conghao Lin, Jingjing Zhang, Qing Li, Zhanyong Guo*. Development of antioxidant chitosan-based films incorporated with chitooligosaccharide-caffeic acid conjugates. Food Hydrocolloids, 2023, 138, 108431.
12. Qing Li, Heng Su, Yunhui Yang, Jingjing Zhang, Chuanhai Xia, Zhanyong Guo*. Adsorption property and mechanism of glutaraldehyde-crosslinked chitosan for removal of 2,4-dichlorophenoxyacetic acid from water. Environmental Science-Water Research & Technology. 2022, DOI: 10.1039/d2ew00638c。
13. Qin Miao, Qing Li, Wenqiang Tan, Yingqi Mi, Bing Ma, Jingjing Zhang , Zhanyong Guo*. Preparation, Anticoagulant and Antioxidant Properties of Glucosamine-Heparin Salt. Marine Drugs, 2022, 20(10), 646, https://doi.org/10.3390/md20100646.
14. Linqing Wang, Xiguang Liu*, Wenqiang Tan, Qing Li, Zhanyong Guo, Jingjing Zhang*. Preparation and antioxidant activity of novel chitosan oligosaccharide quinolinyl urea derivatives. Carbohydrate Research, 2022, 521, 108678.
15. Jingjing Zhang, Linqing Wang, Wenqiang Tan, Qing Li, Fang Dong, Zhanyong Guo*. Preparation of chitosan-rosmarinic acid derivatives with enhanced antioxidant and anti-inflammatory activities. Carbohydrate Polymers, 2022, 296, 15, 119943
16. Yuting Yuan, Wenqiang Tan, Jingjing Zhang, Qing Li, Zhanyong Guo*. Water-soluble amino functionalized chitosan: Preparation, characterization, antioxidant and antibacterial activities. International Journal of Biological Macromolecules, 2022, 217, 969-978.
17. Yan Sun, Xia Ji, Jingmin Cui, Yingqi Mi, Jingjing Zhang, Zhanyong Guo*. Synthesis, Characterization, and the Antioxidant Activity of Phenolic Acid Chitooligosaccharide Derivatives Marine Drugs, 2022, 20(8), 489, https://doi.org/10.3390/md20080489
18. Yingqi Mi, Jingjing Zhang, Wenqiang Tan, Qin Miao, Qing Li, Zhanyong Guo*. Preparation of doxorubicin-loaded carboxymethyl-β-cyclodextrin /chitosan nanoparticles with antioxidant, antitumor activities and pH-sensitive release. Marine Drugs, 2022, 20(5), 278; https://doi.org/10.3390/md20050278.
19. Yingqi Mi, Qing Li, Qin Miao, Wenqiang Tan, Jingjing Zhang, Zhanyong Guo*. Enhanced antifungal and antioxidant activities of new chitosan derivatives modified with Schiff base bearing benzenoid/heterocyclic moieties. International Journal of Biological Macromolecules, 2022, 208, 586-595.
20. Jingjing Zhang, Shijin Zhang, Linqing Wang, Wenqiang Tan, Qing Li, Zhanyong Guo*. The Antioxidant and Antibacterial Activities of the Pyridine-4-Aldehyde Schiff Bases Grafted Chloracetyl Chitosan Oligosaccharide Derivatives. Starch-Stärke, 2022, DOI: 10.1002/star.202100268.
21. Wenqiang Tan, Jingjing Zhang, Yingqi Mi, Qing Li, Zhanyong Guo*. Synthesis and characterization of α-lipoic acid grafted chitosan derivatives with antioxidant activity. Reactive and Functional Polymers, 2022, 172, 105205.
22. Jingmin Cui, Xia Ji*, Yingqi Mi, Qin Miao, Fang Dong, Wenqiang Tan, Zhanyong Guo*. Antimicrobial and Antioxidant Activities of N-2-Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Amino Acid Schiff Bases. Marine Drugs 2022, 20(2), 86, https://doi.org/10.3390/md20020086.
23. Jingjing Zhang, Wenqiang Tan, Qing Li, Xiaorui Liu, Zhanyong Guo*. Facile synthesis, characterization, antioxidant activity, and antibacterial activity of carboxymethyl inulin salt derivatives. International Journal of Biological Macromolecules, 2022, 199, 138-149.
24. Yingqi Mi, Yuan Chen, Wenqiang Tan, Jingjing Zhang, Qing Li, Zhanyong Guo*. The influence of bioactive glyoxylate bearing Schiff base on antifungal and antioxidant activities to chitosan quaternary ammonium salts. Carbohydrate Polymers, 2022, 278, 118970.
25. Yingqi Mi, Yuan Chen, Guodong Gu, Qin Miao, Wenqiang Tan, Qing Li, Zhanyong Guo*. New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release. Carbohydrate Polymers, 2021, 273, 118623.
26. Jingjing Zhang, Wenqiang Tan, Qing Li, Xiaorui Liu, Zhanyong Guo*. Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for AntibacterialWound Dressing. Marine Drugs, 2021, 19, 479. https://10.3390/md19090479.
27. Lijie Wei, Haishan Sui, Jingjing Zhang, Zhanyong Guo*. Synthesis and antioxidant activity of the inulin derivative bearing 1,2,3-triazole and diphenyl phosphate. International Journal of Biological Macromolecules, 2021, 186, 47-53.
28. Yingqi Mi, Jingjing Zhang, Lulin Zhang, Qing Li, Yuanzheng Cheng*, Zhanyong Guo*. Synthesis, Characterization, and Evaluation of Nanoparticles Loading Adriamycin Based on 2-Hydroxypropyltrimethyl Ammonium Chloride Chitosan Grafting Folic Acid. Polymers, 2021, 13(14), 2229, https://doi.org/10.3390/polym13142229
29. Qin Miao, Yingqi Mi, Yulin Cui, Jingjing Zhang, Wenqiang Tan, Qing Li, Zhanyong Guo*. Determination of chitosan content with Schiff base method and HPLC. International Journal of Biological Macromolecules, 2021, 182, 1537-1542.
30. Yingqi Mi, Jingjing Zhang, Xiangru Han, Wenqiang Tan, Qin Miao, Jingmin Cui, Qing Li, Zhanyong Guo*. Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities. International Journal of Biological Macromolecules, 2021, 181, 572-581.
31. Xueqi Sun, Jingjing Zhang, Yingqi Mi, Qin Miao, Wenqiang Tan, Qing Li, Zhanyong Guo*. Synthesis, characterization, and the antioxidant activity of carboxymethyl chitosan derivatives containing sulfonium salt. Journal of Oceanology and Limnology, 2021, https://doi.org/10.1007/s00343-021-0352-2.
32. Lijie Wei, Jingjing Zhang, Wenqiang Tan, Gang Wang, Qing Li, Fang Dong, Zhanyong Guo*. Antifungal activity of double Schiff bases of chitosan derivatives bearing active halogeno-benzenes. International Journal of Biological Macromolecules, 2021, 179, 292-298.
33. Wenqiang Tan, Jingjing Zhang, Yingqi Mi, Fang Dong, Qing Li, Zhanyong Guo*. Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction. International Journal of Biological Macromolecules, 2020, 165, Part B, 1765-1772.
34. Qing Li, Qiang Li, Wenqiang Tan, Jingjing Zhang, Zhanyong Guo*. Phenolic-containing chitosan quaternary ammonium derivatives and their significantly enhanced antioxidant and antitumor properties. Carbohydrate Research, 2020, 108169.
35. Qing Li, Yingqi Mi, Wenqiang Tan, Zhanyong Guo*. Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: chemical modification and activity assessment. International Journal of Biological Macromolecules, 2020, 164, 4279-4288.
36. Yingqi Mi, Jingjing Zhang, Yuan Chen, Xueqi Sun, Wenqiang Tan, Qing Li, Zhanyong Guo*. New Synthetic chitosan derivatives bearing Benzenoid/Heterocyclic moieties with Enhanced Antioxidant and Antifungal Activities. Carbohydrate Polymers, 2020, 249, 116847.
37. Qin Miao, Yulin Cui, Jingjing Zhang, Yingqi Mi, Wenqiang Tan, Qing Li, Guodong Gu, Fang Dong, Zhanyong Guo*. Determination of chitosan content with ratio coefficient method and HPLC. International Journal of Biological Macromolecules, 2020, 164, 384-388.
38. Jingjing Zhang, Xueqi Su, Yuan Chen, Yingqi Mi, Wenqiang Tan, Qin Miao, Qing Li, Fang Dong, Zhanyong Guo*. Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities. Carbohydrate Polymers, 2020, 234, 115903.
39. Xueqi Sun, Jingjing Zhang, Yingqi Mi, Yuan Chen, Wenqiang Tan, Qing Li, Fang Dong, Zhanyong Guo*. Synthesis, characterization, and the antioxidant activity of the acetylated chitosan derivatives containing sulfonium salts. International Journal of Biological Macromolecules, 2020, 152, 349-358.
40. Wenqiang Tan, Jingjing Zhang, Xiang Zhao, Qing Li, Fang Dong, Zhanyong Guo⁎. Preparation and physicochemical properties of antioxidant chitosan ascorbate/methylcellulose composite films. International Journal of Biological Macromolecules, 2020, 146, 53-61.
41. Yuan Chen, Yingqi, Mi, Xueqi Sun, Jingjing Zhang, Qing Li, Naiyun Ji, Zhanyong Guo*. Synthesis of Schiff bases modified inulin derivatives for potential antifungal and antioxidant applications. International Journal of Biological Macromolecules, 2020, 143, 714-723.
42. Yukun Qin, Pengcheng Li, Zhanyong Guo*. Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications. Carbohydrate Polymers, 2020, 236, 116002.
六、授权专利
1、郭占勇，秦荣基，谭文强，秦荣珍，董方，姜峰。一种含壳寡糖的复合物及应用，专利号：ZL 202010777934.1。
2、郭占勇，马冰，张晶晶，宓英其。一种含苯并咪唑酸羟丙基三甲基壳聚糖季铵盐衍生物及其制备和应用，专利号：ZL 202311235395.9。
3、郭占勇，韩翔茹，宓英其，张晶晶，李青。一种含巯基酸盐的壳聚糖盐酸盐及其制备方法和应用，专利号：ZL 202311149648.0。
4、郭占勇，袁玉婷，谭文强，王文佳，宓英其。一种两亲性壳聚糖硫辛酸接枝衍生物及其制备和应用。专利号：ZL 202310868370.6。
5、郭占勇，袁玉婷，谭文强，王文佳，宓英其。一种两亲性壳聚糖胱胺接枝衍生物及其制备和应用，专利号：ZL 202310753066.7。
6、郭占勇，秦荣基，谭文强，秦荣珍，董方，姜峰。一种壳寡糖与姜黄素的复合物及应用，专利号：ZL 201911229225.3。
7、郭占勇，袁玉婷，谭文强，林琮皓，宓英其。一种两亲性硫辛酰基阳离子壳聚糖衍生物及其制备和应用，专利号：ZL 202310486747.1。
8、郭占勇，陈源。一种含希夫碱的菊糖衍生物及其制备方法和应用，专利号：ZL201910283581.7。
9、郭占勇，宓英其，秦荣基，秦荣珍，李青。一种含氨基吡啶的羧甲基壳聚糖及其制备方法和应用，专利号：ZL 201910829859.6。
10、郭占勇，王林卿，张晶晶，谭文强，李青。一种含喹啉基团的壳寡糖季铵盐衍生物及制备方法和应用，专利号：ZL 202211106642.0。
11、郭占勇，孙艳，崔静敏。一种酚酸酯化壳寡糖季铵盐及其制备方法和应用。专利号：ZL 202210971112.6。
12、郭占勇，谭文强，王刚，董方，李青。一种氨基葡萄糖硫酸软骨素盐和制备方法及应用，专利号：ZL 201911241704.7。
13、郭占勇，谭文强，王刚，董方，李青。一种氨基葡萄糖透明质酸盐及应用，专利号：ZL 201911242790.3。
14、郭占勇，林琮皓，谭文强，董方，王刚，李青。一种阳离子菊糖烟酸接枝衍生物及其制备方法和应用，专利号：ZL 202210754488.1。
15、郭占勇，崔静敏，宓英其，苗芹，谭文强，董方。阴离子多糖衍生物的制备方法，专利号：ZL 202111098716.6。
16、郭占勇，陈源，宓英其。一种具有抗氧化活性的吸湿保湿剂及其制备方法和应用，专利号：ZL 201910948985.3。
17、郭占勇，宓英其，谭文强，张晶晶，李青。一种含噻唑盐的N,O-羧甲基壳聚糖及其制备和应用，专利号：ZL 202210020179.1。
18、郭占勇，宓英其，秦荣基，秦荣珍，董方。一种含卤代苯的羧甲基壳聚糖及其制备方法和应用，专利号：ZL 201910829860.9。
19、郭占勇，宓英其，张晶晶，崔静敏，李青。一种阴离子化2-羟丙基三甲基氯化铵壳聚糖及制备方法和应用，专利号：ZL 201910746938.0。
20、郭占勇，孙雪琦，张晶晶，宓英其，陈源。一种含锍盐的羧甲基壳聚糖衍生物及其制备方法和应用，专利号：ZL 201910619251.0。
21、郭占勇，谭文强，王刚，董方，李青。一种氨基葡萄糖肝素盐及其应用，专利号：ZL 201911242820.0。
22、郭占勇，李青，谭文强，张晶晶。一种香豆素类菊糖衍生物及其制备和应用，专利号：ZL 201910660091.4。
23、郭占勇，孙雪琦，杨宇强，张晶晶，宓英其，陈源。一种含硫脲盐的羧甲基壳聚糖衍生物及其制备方法和应用，专利号：ZL201910811439.5。
24、郭占勇，谭文强，王刚，董方，李青。含壳寡糖、菊糖、鞣花酸两种或以上的复合物及应用。专利号：ZL 201911249528.1。
七、主要获奖与人才称号
1、山东省有突出贡献的中青年专家，2020-2024年；
2、中国科学院青年创新促进会，2012-2015年；
3、生产力促进（创新发展）奖，二等奖，第叁位，2023年；
4、山东省海洋科技创新奖，一等奖，第叁位，2022年；
5、山东省科技金桥奖，二等奖，第壹位，2021年；
6、中国科学院优秀导师奖，2017、2020、2022、2024年；
7、中国科学院大学朱李月华优秀教师奖，2020年；
8、中国科学院大学领雁银奖.振翅奖，2021、2023年
八、联系方式
邮箱：zyguo@jou.edu.cn
